The Eagles are a desperate team right now and they are also banged up as Reggie Brown (groin) and Brian Westbrook (fractured ribs) are both out this week.  Still, look for the Eagles to air it out with Donovan McNabb and his capable WR corps against the Niners who are allowing 215.6 yards passing per game.  McNabb has been sacked 10 times this season so the Eagles will need to protect him to give him time to get the ball downfield.  That is easier said than done against a Niners’ defense that has 13 sacks this season and 7 interceptions.  Correll Buckhalter is a capable replacement for Brian Westbrook but he’s also a downgrade for the Eagles there.  The Niners are allowing 128.4 yards rushing per game and 3.8 yards per carry so Buckhalter could have a good game.

The 49ers have to run the football in this football game as the Eagles will be putting huge pressure on J.T. O’Sullivan who has been sacked 20 times already this season.  The Eagles have 18 sacks this season as they start blitzing when they get off the team bus and O’Sullivan tends to get rattled when he gets popped a few times.  The way they will try to slow the pass rush is by throwing screens to Frank Gore and also letting him run the ball alot.  He is averaging 120.6 yards rushing and receiving per game this season so look for him to be busy. 

PREDICTION:  PHILADELPHIA EAGLES 20, SAN FRANCISCO 49ERS 16